East Prairie Hotels

    Plan, book, stay with confidence
    bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    today icon
    Change your mind
    Book hotels with free cancellation

Check East Prairie hotel prices

Tomorrow night
This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Top 10 trending East Prairie hotels

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
6.6 out of 10, (531)
"I just want to tell you I stay here a lot. I had never read the reviews before and it didn’t sound like a place I wanted to stay. But the rooms are big. On one side, you can come in from the outside or inside. It is close to halfway for me. Easy to get to. "
The price is P3,624
P4,022 total
includes taxes & fees
Nov 6 - Nov 7
Super 8 by Wyndham Charleston/Sikeston East MO
Quality Inn Cairo I-57
2.5 star property
6.6 out of 10, (236)
"The room was very clean and the breakfast was pretty good. No complaints"
The price is P3,364
P3,733 total
includes taxes & fees
Dec 6 - Dec 7
Quality Inn Cairo I-57
Quality Inn Charleston - Sikeston
2.5 star property
6.8 out of 10, (357)
"Great bed. "
The price is P3,485
P3,868 total
includes taxes & fees
Dec 6 - Dec 7
Quality Inn Charleston - Sikeston
Eagle Inn Charleston
2.0 star property
6.8 out of 10, (95)
"Comfortable bed, easy access to room"
The price is P4,043
P4,488 total
includes taxes & fees
Nov 15 - Nov 16
Eagle Inn Charleston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in East Prairie
Save an average of 15% on thousands of hotels when you're signed in

Frequently asked questions

What's the best place for a stay in East Prairie?

Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay based on our traveler data. Other good options for your visit to the area are Pear Tree Inn Sikeston and Days Inn and Suites by Wyndham Sikeston. See all available top hotels, or vacation rentals in East Prairie.

If I need to cancel my hotel reservation in East Prairie, will I receive a refund?

Yes! The majority of hotel room reservations are fully refundable if you cancel before the hotel’s cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.

Where can I learn more about changing or cancelling my trip to East Prairie?

To access more information about rescheduling or cancelling your trip to East Prairie, click here.

What are some hotels with pools in East Prairie?

Best Western Plus Sikeston: Features free full breakfast, a pool, and free parking. Pear Tree Inn Sikeston and Drury Inn & Suites Sikeston, MO are a couple of other choices that offer an onsite pool. View all hotels with pools in East Prairie.

What's the best hotel for staying near Cape Girardeau Municipal Airport (CGI)?

Candlewood Suites Cape Girardeau is one of the top choices for your stay and is a popular hotel, featuring an indoor pool and free WiFi. It's located 4.4 mi (7 km) from Cape Girardeau Municipal Airport.

What's it like to stay in East Prairie?

Visitors are sure to enjoy all that East Prairie has to offer. There are 29 hotels and other accommodations in the surrounding area. Find out more about East Prairie.

What should I do while I'm visiting East Prairie?

The picturesque setting of Mississippi River and Big Oak Tree State Park exemplify the area's natural beauty. You'll also find The Book Bug and New Madrid Historical Museum in the area. Check out what more to see and do in Expedia's East Prairie guide.

What's the weather like in East Prairie?

The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for East Prairie is 60 inches.