Cairo Hotels

    calendar shield illustration
    Change your mind
    Book hotels with free cancellation
    deals illustration
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration
    Be picky
    Search almost a million properties worldwide

Check prices for these dates

Tonight
Jul 6 - Jul 7
Tomorrow
Jul 7 - Jul 8
Next weekend
Jul 11 - Jul 13
In two weeks
Jul 18 - Jul 20

Filter by

Guest rating
Guest rating
Star rating

Top 10 trending Cairo hotels

Quality Inn Cairo I-57
Lobby

Quality Inn Cairo I-57

2.5 star property
6.6 out of 10, (260)
"Stay here almost weekly. Very quiet, not around anything other than a dollar general which is good. Just a bit pricey for a night. "
The price is P4,005
P4,444 total
includes taxes & fees
Jul 18 - Jul 19
Quality Inn Cairo I-57
La Center Motel
1 bedroom, free WiFi

La Center Motel

2.0 star property
7.8 out of 10, Good, (14)
"Front desk staff was amazing. Room was comfy and quiet! Clean! Husband and I needed a place to crash on our long ride home and this motel did not disappoint!"
La Center Motel
Eagle Inn Charleston
Desk, iron/ironing board, free WiFi, alarm clocks

Eagle Inn Charleston

2.0 star property
6.8 out of 10, (100)
"Comfortable bed, easy access to room"
The price is P3,724
P4,132 total
includes taxes & fees
Jul 8 - Jul 9
Eagle Inn Charleston
Quality Inn Charleston - Sikeston
Desk, laptop workspace, blackout drapes, iron/ironing board

Quality Inn Charleston - Sikeston

2.5 star property
6.8 out of 10, (387)
"Very friendly and accommodating "
The price is P3,964
P4,399 total
includes taxes & fees
Jul 30 - Jul 31
Quality Inn Charleston - Sikeston
Super 8 by Wyndham Charleston/Sikeston East MO
Front of property - evening/night

Super 8 by Wyndham Charleston/Sikeston East MO

2.0 star property
6.6 out of 10, (570)
"Gross"
The price is P3,656
P4,058 total
includes taxes & fees
Jul 30 - Jul 31
Super 8 by Wyndham Charleston/Sikeston East MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

These family-friendly hotels in Cairo may fit your trip

Quality Inn Cairo I-57
Lobby

Quality Inn Cairo I-57

2.5 star property
6.6 out of 10, (260)
The price is P4,005
P4,444 total
includes taxes & fees
Jul 18 - Jul 19
Quality Inn Cairo I-57
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Cairo

Escape to quaint Cairo! Enjoy its ruins, history, and entertainment.

See all hotels in Cairo

Frequently asked questions

Where is the best place for a stay in Cairo?

Based on our traveler data, Quality Inn Cairo I-57 is one of the top choices for your stay. This hotel offers free breakfast and free parking. Other good choices for your trip to the area are Quality Inn Charleston - Sikeston and Super 8 by Wyndham Charleston/Sikeston East MO. See all available top hotels, or vacation rentals in Cairo.

If I need to cancel my hotel reservation in Cairo, will I receive a refund?

Yes! Most hotel room reservations are refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Cairo.

Where can I learn more about changing or cancelling my trip to Cairo?

For more information about updating your trip to Cairo or cancelling it, head over to our customer service page.

Where is the best hotel to stay close to Fort Defiance?

Quality Inn Cairo I-57 is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and free parking. It's located 4.9 mi (7.8 km) from Fort Defiance. Other good options around the area include Victorian Splendor in So. Illinois: wallmanor.com and Eagle Inn Charleston.

What are some hotels with pools in Cairo?

Quality Inn Cairo I-57 is a top hotel with a seasonal outdoor pool, free full breakfast, and free WiFi.

What's the best hotel for staying near Barkley Regional Airport (PAH)?

Drury Inn & Suites Paducah is one of the top choices for your stay and is a popular 3-star hotel featuring free breakfast and an indoor pool. It's located 4.7 mi (7.6 km) from Barkley Regional Airport. Other choices close to the airport include La Quinta Inn & Suites by Wyndham Paducah and Baymont by Wyndham Paducah.

What is staying in Cairo like?

Visitors can enjoy all that Cairo has to offer including the restaurants, entertainment choices, and riverfront. This city also attracts tourists with its small-town vibe. There are 22 hotels and other accommodations in the surrounding area. Find out more about Cairo.

What should I see while I'm in Cairo?

A couple of favorite places to visit are Mississippi River and Fort Defiance State Park. You'll also find Columbus-Belmont State Park and Ullin City Hall in the area. Check out what more to see and do in Expedia's Cairo guide.

What's the seasonal weather like in Cairo?

The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Cairo is 61 inches.