Otay Mesa

San Diego


Popular places to visit

Things to do


Top hotels in Otay Mesa

Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
The price is P8,605 per night from Jul 2 to Jul 3
P8,605
P11,617 total
Jul 2 - Jul 3
includes taxes & fees
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,701 reviews)
"Hotel is very nice, clean and comfortable, located in great location. Price was reasonable. We did have a very distasteful thing happen that warrants warning to future guests. We arrived early after flight from E coast. When leaving bags for day (easy), we were approached by concierge. We were invited ..."

Reviewed on Jun 25, 2025

Wyndham San Diego Bayside
Marriott Marquis San Diego Marina
Marriott Marquis San Diego Marina
4 out of 5
333 W Harbor Dr, San Diego, CA
The price is P13,913 per night from Jul 6 to Jul 7
P13,913
P18,700 total
Jul 6 - Jul 7
includes taxes & fees
Book a stay at this spa hotel in San Diego. Enjoy 2 outdoor pools, a full-service spa, and 5 restaurants. Our guests praise the pool and the helpful staff in ...
9/10 Wonderful! (1,727 reviews)
"Went to the marriot to celebrate mine and my fiances anniversary, we had a blast. Great customer service always"

Reviewed on Jun 27, 2025

Marriott Marquis San Diego Marina
Handlery Hotel
Handlery Hotel
3.5 out of 5
950 Hotel Cir N, San Diego, CA
The price is P5,764 per night from Jul 2 to Jul 3
P5,764
P6,625 total
Jul 2 - Jul 3
includes taxes & fees
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our ...
8/10 Very Good! (1,825 reviews)
"I love everything about hotel. Food is good. Pamela and Julia are AMAZING!!"

Reviewed on Jun 26, 2025

Handlery Hotel
Manchester Grand Hyatt San Diego
Manchester Grand Hyatt San Diego
4 out of 5
1 Market Pl, San Diego, CA
The price is P10,689 per night from Jul 2 to Jul 3
P10,689
P15,486 total
Jul 2 - Jul 3
includes taxes & fees
Stay at this 4-star eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
9/10 Wonderful! (2,779 reviews)
"This is a beautiful property; however, checking in took over 30 minutes because the front desk was understaffed. A hotel this big should have more than two people working at the front desk."

Reviewed on Jun 26, 2025

Manchester Grand Hyatt San Diego
Hyatt Regency Mission Bay Spa and Marina
Hyatt Regency Mission Bay Spa and Marina
4 out of 5
1441 Quivira Rd, San Diego, CA
The price is P14,083 per night from Jun 30 to Jul 1
P14,083
P18,978 total
Jun 30 - Jul 1
includes taxes & fees
Stay at this 4-star spa hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.4/10 Very Good! (1,469 reviews)
"I thought this was going to be a treat, spent a lot of a room. The pictures make it seem like you are staying in the tower, but actually for queen bed room you are staying in other 2 story buildings that do not have elevators and are far from parking."

Reviewed on Jun 28, 2025

Hyatt Regency Mission Bay Spa and Marina
Kings Inn San Diego
Kings Inn San Diego
2.5 out of 5
1333 Hotel Cir S, San Diego, CA
The price is P7,330 per night from Jun 30 to Jul 1
P7,330
P8,411 total
Jun 30 - Jul 1
includes taxes & fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
8.6/10 Excellent! (3,286 reviews)
"Nice little motel off i5 in a complex with other hotels. Has a breakfast restaurant in the lobby. Parking was a little tight near the rooms, but otherwise our stay was nice. The pool area is clean and well lit and was full of families with children, so the area is very safe"

Reviewed on Jun 27, 2025

Kings Inn San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Otay Mesa

Lake Murray in San Diego

Mid-City

If you're spending time in Mid-City, check out sights like Cal Coast Credit Union Open Air Theater or Viejas Arena and hop on the metro to see more the city at SDSU Transit Center Station or Alvarado Station.

Mid-City
Gaslamp Quarter showing signage, night scenes and street scenes

Gaslamp Quarter

Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Harlem of the West Sites is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.

Gaslamp Quarter
US Grant Hotel

Downtown San Diego

Seaport Village and Petco Park are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.

Downtown San Diego
Try the tamale eggs Benedict!

North Park

North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum.

North Park
Little Italy

Little Italy

Little Italy is popular for its captivating waterfront views. Explore top sights like Maritime Museum of San Diego and San Diego Bay, and you can get around town on the metro at County Center - Little Italy Station.

Little Italy
Default Image

Del Cerro

Del Cerro might not have many top sights, but Cal Coast Credit Union Open Air Theater and Viejas Arena are two attractions nearby that you can check out.

Del Cerro

Otay Mesa