South Main Trips (flight + hotel)

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Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most. Learn more about South Main
Discovery Green which includes a square or plaza, city views and a city

Downtown Houston

3 out of top 10 points of interest in this area

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

Find hotels in Downtown Houston

Top hotels in South Main

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
5353 Westheimer Rd Houston TX
Fully refundableReserve now, pay when you stay
The price is P7,482 per night from Dec 22 to Dec 23
P7,482
P8,815 total
Dec 22 - Dec 23
includes taxes & fees
8.2/10 Very Good! (3,085 reviews)
The room was immaculate. Beautiful property, self parking wasn't too bad either.

Reviewed on Dec 15, 2025

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
The price is P16,002 per night from Dec 16 to Dec 17
P16,002
P21,265 total
Dec 16 - Dec 17
includes taxes & fees
8.8/10 Excellent! (1,839 reviews)
Great service

Reviewed on Dec 4, 2025

Hotel Zaza Houston Museum District
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street Houston TX
Fully refundableReserve now, pay when you stay
The price is P4,694 per night from Dec 27 to Dec 28
P4,694
P5,492 total
Dec 27 - Dec 28
includes taxes & fees
8.4/10 Very Good! (3,924 reviews)
Room was clean, wish they could have explained the parking in more detail but it was a nice stay

Reviewed on Dec 8, 2025

Club Quarters Hotel Downtown, Houston
See all 6,793 properties in South Main
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a South Main vacation package cost?
Get set to book, because a getaway to South Main starts from an enticing . When you combine your flights, hotels and more into a travel package, you'll walk away with the best bargains.
How do I get a cheap travel package to South Main?
You'll save tons of cash if you bundle your car rentals, hotels and flights into a South Main vacation package. Sometimes cheap means fewer options. But that's not the case with Expedia. We offer over 550 airlines and 1,000,000 hotels across the globe, which means you'll always have plenty of variety to choose from. Like to save even more? Add some interesting activities to your package deal to unlock even bigger bargains! After all, travel is about more than just getting to your destination.
Where should I stay in South Main?
Book a hotel within walking distance of Houston Zoo, one of this neighborhood's most popular attractions. It's the perfect spot if you're an eager sightseer.
What are the top hotels in South Main?
Get your trip off to a fantastic start by booking a stay at Travelers Dream 1bd 1 Bath Getaway. It's one of most popular hotels in South Main. Another welcoming option is Luxury King And Queen 1bedroom Suite | Nrg Stadium | Medical Ctr | Galleria | Downtown.
How far in advance should I book my South Main vacation?
It all depends on the air carrier, but you can usually browse through international airfares on Expedia nearly a year in advance. While it's a good idea to book ahead of time, lucky customers occasionally find a cheaper seat just weeks before the date of departure.
What does an Expedia South Main travel package include?
Flights, car rentals and hotels — we bring you all the best deals. All you have to do is figure out your favorite combination. Once you've made your booking, you can add on the exciting stuff like sightseeing activities. Our travel packages make it easy to customize an unforgettable South Main vacation.
What should I know before booking a South Main travel package?
You can save big by bundling your hotels, airfares and rental cars. Once you've made your booking, you can add on things like sightseeing tours or experiences. Your next unforgettable adventure is only a couple of clicks away.
Can I choose my airline with a South Main Expedia vacation package?
You certainly can. Expedia has access to more than 550 airline partners around the world, so fly with the carrier that best suits your needs.
If I'm not able to travel, can I cancel my South Main vacation package?
It's hard to predict what the future holds, so it's comforting to know that you can change or cancel your South Main vacation package. If you made your booking in the last 24 hours, you may be entitled to a refund. If it's an older booking, your airline, hotel or car rental company may charge a fee. Visit our Customer Service Portal to learn more.

Popular places to visit

NASA Johnson Space Center

NASA Johnson Space Center

After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.

NASA Johnson Space Center
Toyota Center

Toyota Center

Catch an event at Toyota Center during your trip to Houston. Experience the acclaimed theater scene and entertainment choices in this vibrant area.

Toyota Center
Houston Zoo showing zoo animals and land animals

Houston Zoo

With a huge collection of animals, a water park and a cinema, Houston Zoo is a great day out for the family.

Houston Zoo

Things to do

Houston Museum of Natural Sciences: Planetarium Ticket

Houston Museum of Natural Sciences: Planetarium Ticket

P705
per adult
84% of travellers recommend
Houston Museum of Natural Sciences: Planetarium Ticket
Houston Space Center

Space Center Houston Admission Ticket

P1,918
per adult
92% of travellers recommend
Space Center Houston Admission Ticket
Houston: Museum of Natural Science General Admission Ticket

Houston Museum of Natural Science General Admission Ticket

P1,470
per adult
96% of travellers recommend
Houston Museum of Natural Science General Admission Ticket
See all activities in Houston
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.