South Main Hotels near Houston
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Top Trending Hotels Near South Main, Houston

Comfort Suites near Texas Medical Center - NRG Stadium
Comfort Suites near Texas Medical Center - NRG Stadium

Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHG

Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical Center

Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical Center

Hotel ZaZa Houston Memorial City
Hotel ZaZa Houston Memorial City
Where to stay in South Main

Downtown Houston
Known for its abundant dining options and live music, there's plenty to explore in Downtown Houston. Top attractions like Toyota Center and Daikin Park are major draws, and you can catch the metro at Central Station Main or Theater District Station to see more of the city.

The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

Texas Medical Center
Well-liked for its restaurants, museums, and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo is a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Westheimer Rd while you're exploring the area.

Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Main Street Square Station.
Recent Reviews in South Main
Recent Reviews in South Main

Blossom Hotel Houston
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Destinations near Houston
- Hotels in Downtown Houston
- Hotels in The Galleria
- Hotels in Texas Medical Center
- Hotels in Montrose
- Hotels in Houston Central Business District
- Hotels in Houston Heights
- Hotels in Washington Ave./ Memorial Park
- Hotels in Northside
- Hotels in Midtown
- Hotels in South Central Houston
- Hotels in Astrodome
- Hotels in Westchase
- Hotels in Houston Museum District
- Hotels in Atascocita
- Hotels in Northeast Houston
- Hotels in South Main
- Hotels in Greater Uptown
- Hotels in Memorial
- Hotels in Greenway Plaza-Upper Kirby
- Hotels in North Houston
Destinations near Houston
Most Popular Hotels in South Main
- Holiday Inn Houston Downtown by IHG
- Marriott Marquis Houston
- Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
- Aloft Houston Downtown
- DoubleTree by Hilton Hotel Houston - Greenway Plaza
- Hilton Houston Plaza/Medical Center
- The Westin Oaks Houston at the Galleria
- Hotel Zaza Houston Museum District
- Omni Houston Hotel
- SpringHill Suites by Marriott Houston Intercontinental Arprt