Santee Hotels

  • Plan, book, stay with confidence
  • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    today icon
    Change your mind
    Book hotels with free cancellation

Check Santee hotel prices

Tomorrow night
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Top 10 trending Santee hotels

Spacious, Scenic Wagner Haven w/ River Access

3.0 star property
8.0 out of 10, Very Good, (1)
Spacious, Scenic Wagner Haven w/ River Access
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in Santee
Save an average of 15% on thousands of hotels when you're signed in

Frequently asked questions

If I need to cancel my hotel reservation in Santee, will I receive a refund?

Yes! The majority of hotel room reservations are fully refundable as long as you cancel before the hotel’s cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Santee.

Where can I learn more about changing or cancelling my trip to Santee?

For more information about rescheduling or cancelling your trip to Santee, click here.

What are some hotels with pools in Santee?

Lewis and Clark Resort: Features free parking, an outdoor pool, and free WiFi. View all hotels with pools in Santee.

What is staying in Santee like?

Those traveling to Santee are sure to enjoy the sights to see and things to do. There are 56 hotels and other accommodations in the surrounding area. Find out more about Santee.

What are the top places to visit in Santee?

A favorite place to visit is Lewis and Clark Lake. You'll also find Niobrara State Park and Lewis and Clark Recreation Area in the area. Check out what more to see and do in Expedia's Santee guide.

What's the weather like in Santee?

The hottest months are usually July and August with an average temp of 72°F, while the coldest months are January and February with an average of 26°F. The snowiest months in Santee are January, December, October, and March, with each month seeing an average of 8 inches of snowfall.