Southeastern Indiana Trips (flight + hotel)

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Where to stay in Southeastern Indiana

Find the best Southeastern Indiana areas and neighborhoods for the activities you enjoy most. Learn more about Southeastern Indiana
Louisville Science Center featuring outdoor art

West Main Historic District

West Main Historic District is beloved for its fantastic nightlife. Take some time to explore sights in the area like Frazier International History Museum and Louisville Slugger Museum.

Find hotels in West Main Historic District

Top hotels in Southeastern Indiana

Radisson Hotel Louisville North

Radisson Hotel Louisville North

3 out of 5
505 Marriott Drive Clarksville IN
Fully refundable
The price is P3,697 per night from Jan 25 to Jan 26
P3,697
P4,178 total
Jan 25 - Jan 26, 2026
includes taxes & fees
6.8/10 (2,650 reviews)
Staff

Reviewed on Dec 21, 2025

Radisson Hotel Louisville North
Hilton Garden Inn Jeffersonville Louisville North

Hilton Garden Inn Jeffersonville Louisville North

3 out of 5
4900 Water Tower Road Jeffersonville IN
Fully refundableReserve now, pay when you stay
The price is P6,213 per night from Dec 30 to Dec 31
P6,213
P7,020 total
Dec 30 - Dec 31
includes taxes & fees
9.4/10 Exceptional! (418 reviews)
nice hotel, nice staff and bar.

Reviewed on Dec 23, 2025

Hilton Garden Inn Jeffersonville Louisville North
Comfort Inn & Suites Clarksville - Louisville North

Comfort Inn & Suites Clarksville - Louisville North

2.5 out of 5
1485 Broadway St Clarksville IN
Fully refundableReserve now, pay when you stay
The price is P5,437 per night from Jan 16 to Jan 17
P5,437
P6,144 total
Jan 16 - Jan 17, 2026
includes taxes & fees
8.8/10 Excellent! (1,007 reviews)
Room is beautiful! Excellent condition and clean! Staff is very friendly and accommodating! I recommend this Comfort Inn if you are looking in this area.

Reviewed on Dec 20, 2025

Comfort Inn & Suites Clarksville - Louisville North
See all 1,146 properties in Southeastern Indiana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Louisville Waterfront Park

Louisville Waterfront Park

After visiting Louisville Waterfront Park, make a plan to see the other sights and activities in Louisville. Stroll along the area's riverfront or experience its lively festivals.

Louisville Waterfront Park

Kentucky Bourbon Trail Visitor Center

Kentucky Bourbon Trail Visitor Center is just one of the places to see in Louisville, so why not enjoy the other things to explore during your travels? Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

Kentucky Bourbon Trail Visitor Center

Nulu Market Place

You can find the perfect gifts to bring home at Nulu Market Place during your trip to Louisville. Attend a sporting event or simply enjoy the lively bars while you're in the area.

Nulu Market Place

Frequently asked questions

Can I cancel my flight booking to Southeastern Indiana due to COVID-19?
If you haven't booked yet, check the terms and conditions of the airline you're considering. If you've already reserved your flight to Southeastern Indiana, head to our Customer Service Portal. The information here will help determine which COVID-19 policies apply to your booking and provide advice on the next steps.
What's the best way to find cheap flights to Southeastern Indiana that have flexible change policies?
It's as easy as 1-2-3 with Expedia. Firstly, type in your preferred dates and destination and press "Search." Next, check the "No change fee" box directly below the "Flexible change policies" subheading to the left of the screen. Step 3. Reserve a cheap and flexible airfare to Southeastern Indiana.
What are some of the general tips for travelers to Southeastern Indiana during the COVID-19 outbreak?
With strict COVID-19 precautions to adhere to, travel looks a bit different these days. Here's what you should know before you jet off to Southeastern Indiana:
  • Research if any travel restrictions apply to your origin and destination before locking in a flight. Also check if there are any conditions you'll have to follow on arrival, such as proof of a negative COVID-19 test.
  • You must wear a face mask at the airport, including at security checkpoints. You should be prepared to lower your mask for identification purposes when asked by a TSA employee.
  • To minimize the risk of cross-contamination, place your boarding pass on the reader yourself and then hold it up for inspection. Do not hand your pass directly to a TSA officer.
  • TSA now allows passengers to take one container of hand sanitizer, up to 12 oz (350 ml) in size, in carry-on bags. This will need to be removed from your bag at the X-ray machine for screening.
  • Place any personal items (e.g, keys, phone and wallet) in your carry-on instead of a bin to minimize handling during screening.
  • Transport all food items in a clear plastic bag and also place them in a screening bin. Keeping food separate from your carry-on makes it less likely that a TSA officer will need to touch and open your bag for inspection.

Which airlines fly to Southeastern Indiana?
Let American Airlines fly you there. This renowned carrier operates 13307 services per month to O'Hare Intl. Airport (ORD), a Southeastern Indiana gateway.
How can I find cheap tickets to Southeastern Indiana?
An effective strategy for picking up cheap fares is to be flexible with your travel dates. Start by searching for your flight to Southeastern Indiana, then click on the "flexible dates" link to see prices for nearby days. Another handy tip? Book well ahead. For an idea of costs, was the best price for a flight to Southeastern Indiana in the last seven days.
How much is a flight to Southeastern Indiana?
In the last seven days, round-trip airfares to Southeastern Indiana sold for as low as and reached a maximum price of . For one-way journeys departing from (), the lowest price during this time was only .
What are the most popular airports to fly into in Southeastern Indiana?
Fly into O'Hare Intl. Airport (ORD) and sample the best that Southeastern Indiana has to offer. As the region's main point of entry, roughly 33491 flights land here every month.
When is the cheapest time to fly to Southeastern Indiana?
Leave for Southeastern Indiana earlier in the week and you'll usually be rewarded with more affordable fares. Tuesday is generally the cheapest day to jump on a plane, followed closely by Monday. If you'd like to avoid the priciest flights, steer clear of Saturdays.
How much is a plane ticket to Southeastern Indiana?
In the last seven days, airfares ranged between and . Scroll through our sensational deals to Southeastern Indiana, pick your favorite and then get ready for your getaway!
Which airlines with flights to Southeastern Indiana employ COVID-19 cleanliness policies?
While flying in the middle of a pandemic can be nerve-wracking, airlines have been working hard to ensure the well-being of all on board. Here are a few carriers that have implemented changes:
  • United Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant.

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