Southeast Missouri Trips (flight + hotel)

Cross off another part of the world with our Southeast Missouri vacation packages, which start from just . Select the flights and hotels that match your travel plans. Then, add on one or two tours or experiences for an unforgettable adventure.

Browse and book everything in the one place with our Southeast Missouri vacation packages. You’ll find deals on flights, hotels, tours and more that’ll keep your pocket happy and your adventurous spirit alive. And, with more than 550 partner airlines and 1,000,000 hotels around the world to select from, you’ll have endless opportunities to mix and match your own way.

When it comes to properties in Cape Girardeau, Drury Plaza Hotel Cape Girardeau Conference Center and Pear Tree Inn Cape Girardeau West are a couple of favorites. If you’re considering heading to Ste Genevieve, City Place St. Louis Downtown and The Branson Hillside Hotel are waiting to welcome you.

It’s tricky picking the perfect time for airfares, but we generally say the earlier, the better. Many international journeys on Expedia become available up to a year in advance. If you can’t book ahead, don’t worry. Cheap prices appear from time to time within a few weeks of departure dates.

From hotels and flights to car rentals, Expedia can help you craft a Southeast Missouri package that fits you. Vacationing for a week or two? Look into a rental car, hotel and flight bundle. If you’re taking a quick break, a hotel and airfare deal may suit you better. Experiences can also be added once you’ve made your booking. Our packages make it a breeze to plan and save.

When you book your flights, hotels and car rentals together, you’ll pick up terrific discounts. Whether you’re planning a beach escape in a villa or prefer to stay in a comfortable hotel in the city, Expedia will help make it happen.

You can, and with over 550 airlines to pick from around the world, you’re spoiled for choice. Have a look through the available options and see which airline best suits your budget and needs.

Because we understand life is full of surprises, the answer is yes. To learn more, head to our Customer Service Portal. But generally speaking, if you’ve booked your Southeast Missouri vacation package in the last 24 hours, you may be able to cancel or change it for no charge. Your hotel, airline or car rental company may charge a fee if your booking is older than that.