If you're looking forward to lots of outings with your partner, check out these details about year-round temperatures in Santa Fe de Antioquia: The hottest months are usually August and July with an average temp of 66°F, while the coldest months are December and January with an average of 64°F. The rainiest months in Santa Fe de Antioquia are May, April, October, and November, with each month seeing an average of 16 inches of rainfall.