San Francisco

Panama City

Photo by Hideki Yamagata
Photo by Hideki Yamagata
Photo by ‎James Barrow
Photo by ‎James Barrow
Photo by Adrian Damian
Photo by Adrian Damian
Photo by Nóra Széll
Photo by Nóra Széll
Photo by Panama Roadrunner
Photo by Panama Roadrunner

Popular places to visit

Multiplaza Pacific Mall

Multiplaza Pacific Mall

During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall

ATLAPA Conventions Center

Learn about the events happening at ATLAPA Conventions Center during your trip to Panama City. Stroll along the seaside in this vibrant area, or check out its lively bars.

ATLAPA Conventions Center

Multicentro Panama

During your trip to Panama City, you can find the perfect gifts to bring home at Multicentro Panama. Stroll along the seaside or visit the casinos in this vibrant area.

Multicentro Panama

Pacific Center

You can enjoy retail therapy at Pacific Center during your visit to Panama City. You can enjoy the restaurants while in the area.

Pacific Center

Panama Canal Murals

You can learn about the history of Panama City with a visit to Panama Canal Murals. Stroll along the seaside in this vibrant area, or check out its top-notch restaurants.

Panama Canal Murals

Hospital Punta Pacífica

Though Hospital Punta Pacífica might be what brings you to town, perhaps you'll have a chance to explore more of Panama City while you are here.

Hospital Punta Pacífica

Things to do

Day Tour

Day Tour in San Blas Islands All Included Visiting 4 Islands

P8,544
per adult
94% of travellers recommend
Day Tour in San Blas Islands All Included Visiting 4 Islands
The Cathedral Basilica of Santa María La Antigua stands as a monumental beacon of faith, the first of its kind in America. Consecrated in 1796, its foundations were laid in 1688, marking over a centur

HALF-DAY City and Panama Canal Tour: Shared or Private

P4,759
per adult
100% of travellers recommend
HALF-DAY City and Panama Canal Tour: Shared or Private
La casa de papel Day tour in San Blas Islands - All inclusive- No hidden fees.

All included - Day tour in San Blas Islands - No extra fees

P6,250
per adult
All included - Day tour in San Blas Islands - No extra fees
Boat Tour to Monkey Island in the Panama Canal

Boat tour in the Panama Canal to Monkeys and sloths islands

P4,243
per adult
92% of travellers recommend
Boat tour in the Panama Canal to Monkeys and sloths islands
Full-Day SAN BLAS ISLAND & Snorkeling Tour + Transport from Panama City

Full-Day SAN BLAS ISLAND Tour + Transport from Panama City

P8,200
per adult
Full-Day SAN BLAS ISLAND Tour + Transport from Panama City
Live the Experience of a Full Day in San Blas

Live the Experience of a Full Day in San Blas

P9,461
per adult
100% of travellers recommend
Live the Experience of a Full Day in San Blas
See all activities in Panama City

Top hotels in San Francisco

Decapolis Hotel Panama City
Decapolis Hotel Panama City
4 out of 5
Avenida Balboa Con Multicentro, Panama City, Panama
The price is P4,827 per night from 5 Apr to 6 Apr
P4,827
P5,310 total
includes taxes & fees
Apr 5 - Apr 6
Stay at this 4-star spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (1,122 reviews)
Just as described
"Fantastic stay. Clean and front desk person was great with providing details about places to visit."

Reviewed on Mar 25, 2025

Decapolis Hotel Panama City
JW Marriott Panama
JW Marriott Panama
5 out of 5
Calle Punta Colon, Punta Pacifica, Panama City, Panama
The price is P10,490 per night from 2 May to 3 May
P10,490
P11,539 total
includes taxes & fees
May 2 - May 3
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff and the property condition ...
8.8/10 Excellent! (1,004 reviews)
"Love the staff"

Reviewed on Mar 24, 2025

JW Marriott Panama
Ramada Plaza By Wyndham Panama Punta Pacífica
Ramada Plaza By Wyndham Panama Punta Pacífica
4 out of 5
Via Israel y Calle 71, San Francisco, Panama City, Panama
The price is P6,871 per night from 1 May to 2 May
P6,871
P7,558 total
includes taxes & fees
May 1 - May 2
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,005 reviews)
"I had a lovely stay despite a little mishap at check in, that got resolved. I loved the variety of foods they had for breakfast. Staff was lovely and friendly. Hotel was very clean. I had the city view room which was beautiful. My only thing was they didn't have a laundry, which was listed apart ..."

Reviewed on Mar 27, 2025

Ramada Plaza By Wyndham Panama Punta Pacífica
Megapolis Hotel Panamá
Megapolis Hotel Panamá
4.5 out of 5
Avenida Balboa, Panama City
The price is P7,274 per night from 5 Apr to 6 Apr
P7,274
P8,001 total
includes taxes & fees
Apr 5 - Apr 6
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
8.2/10 Very Good! (832 reviews)
"10/10"

Reviewed on Mar 18, 2025

Megapolis Hotel Panamá
Plaza Paitilla Inn Hotel
Plaza Paitilla Inn Hotel
3.5 out of 5
Italy Avenue, Punta Paitilla, Winston Churchill Street, Panama City, Panama
The price is P5,398 per night from 8 Apr to 9 Apr
P5,398
P5,938 total
includes taxes & fees
Apr 8 - Apr 9
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool ...
9.2/10 Wonderful! (1,986 reviews)
"Coming back in future"

Reviewed on Mar 30, 2025

Plaza Paitilla Inn Hotel
Las Americas Golden Tower Panama
Las Americas Golden Tower Panama
4 out of 5
Av. Balboa con Calle 53, Paitilla, Panama City, Panama
The price is P8,236 per night from 26 Apr to 27 Apr
P8,236
P9,060 total
includes taxes & fees
Apr 26 - Apr 27
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,006 reviews)
"Central location"

Reviewed on Mar 29, 2025

Las Americas Golden Tower Panama
See all 1,400 properties in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around San Francisco

Summer time in Panama City, blue sky and sunny days to enjoy this city. #lifeatexpedia #PanamaCity #travel

Obarrio

Unique features of Obarrio include the casinos and coffeehouses. Make a stop by Calle 50 or Soho City Center while you're exploring the area.

Obarrio
Default Image

Punta Pacifica

Notable for its seaside views, restaurants, and casinos, Punta Pacifica is a sought-after destination for many travelers visiting Panama City. If you want to see some sights in the area, check out Avenida Balboa or Multiplaza Pacific Mall.

Punta Pacifica
Hard Rock Hotel Panama #StunningStructures

Punta Paitilla

Travelers come to Punta Paitilla for its abundant dining options, and you can see top attractions like Avenida Balboa and Multicentro Panama while you're in town.

Punta Paitilla
Default Image

Campo Alegre

If you're spending some time in Campo Alegre, Uruguay Street and Calle 50 are top sights worth seeing.

Campo Alegre
Default Image

Pueblo Nuevo

While Pueblo Nuevo might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like El Dorado Mall and Multiplaza Pacific Mall.

Pueblo Nuevo
Panama viejo

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

El Cangrejo

San Francisco