San Francisco

Panama City

Photo by Hideki Yamagata
Photo by Hideki Yamagata
Photo by ‎James Barrow
Photo by ‎James Barrow
Photo by Adrian Damian
Photo by Adrian Damian
Photo by Nóra Széll
Photo by Nóra Széll
Photo by Panama Roadrunner
Photo by Panama Roadrunner

Popular places to visit

Multiplaza Pacific Mall

Multiplaza Pacific Mall

During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall

ATLAPA Conventions Center

Learn about the events happening at ATLAPA Conventions Center during your trip to Panama City. Stroll along the seaside in this vibrant area, or check out its top-notch restaurants.

ATLAPA Conventions Center

Multicentro Panama

During your trip to Panama City, you can find the perfect gifts to bring home at Multicentro Panama. Stroll along the seaside or visit the casinos in this vibrant area.

Multicentro Panama

Pacific Center

You can enjoy retail therapy at Pacific Center during your visit to Panama City. You can enjoy the restaurants while in the area.

Pacific Center

Panama Canal Murals

You can learn about the history of Panama City with a visit to Panama Canal Murals. Stroll along the seaside in this vibrant area, or check out its lively bars.

Panama Canal Murals

Hospital Punta Pacífica

Though Hospital Punta Pacífica might be what brings you to town, perhaps you'll have a chance to explore more of Panama City while you are here.

Hospital Punta Pacífica

Things to do

Day Tour

Day Tour in San Blas Islands All Included Visiting 4 Islands

P8,400
per adult
94% of travellers recommend
Day Tour in San Blas Islands All Included Visiting 4 Islands
Panama Hop-On Hop-Off Bus Tour

City Sightseeing Panama City Hop-On Hop-Off Bus Tour

P1,691
per adult
80% of travellers recommend
City Sightseeing Panama City Hop-On Hop-Off Bus Tour
Boat tour in the Panama Canal to Monkeys and sloths islands

Boat tour in the Panama Canal to Monkeys and sloths islands

P4,172
per adult
94% of travellers recommend
Boat tour in the Panama Canal to Monkeys and sloths islands
La casa de papel Day tour in San Blas Islands - All inclusive- No hidden fees.

All included - Day tour in San Blas Islands - No extra fees

P6,145
per adult
All included - Day tour in San Blas Islands - No extra fees
The Cathedral Basilica of Santa María La Antigua stands as a monumental beacon of faith, the first of its kind in America. Consecrated in 1796, its foundations were laid in 1688, marking over a centur

HALF-DAY City and Panama Canal Tour: Shared or Private

P4,679
per adult
100% of travellers recommend
HALF-DAY City and Panama Canal Tour: Shared or Private
Full-Day SAN BLAS ISLAND & Snorkeling Tour + Transport from Panama City

Full-Day SAN BLAS ISLAND Tour + Transport from Panama City

P8,062
per adult
Full-Day SAN BLAS ISLAND Tour + Transport from Panama City
See all activities in Panama City

Top hotels in San Francisco

Sheraton Grand Panama
Sheraton Grand Panama
4 out of 5
Via Israel And 77th Street, Panama City, Panama
The price is P6,187 per night from Jul 18 to Jul 19
P6,187
P6,806 total
Jul 18 - Jul 19
includes taxes & fees
Stay at this 4-star spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition ...
8.4/10 Very Good! (887 reviews)
"I attended an event and thia was well staffed. Beautiful place!"

Reviewed on Jun 30, 2025

Sheraton Grand Panama
JW Marriott Panama
JW Marriott Panama
5 out of 5
Calle Punta Colon, Punta Pacifica, Panama City, Panama
The price is P11,463 per night from Jul 18 to Jul 19
P11,463
P12,609 total
Jul 18 - Jul 19
includes taxes & fees
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff and the property condition ...
8.8/10 Excellent! (1,002 reviews)
"Great location, a lot of nice amenities. I highly recommend."

Reviewed on Jun 25, 2025

JW Marriott Panama
Ramada Plaza By Wyndham Panama Punta Pacífica
Ramada Plaza By Wyndham Panama Punta Pacífica
4 out of 5
Via Israel y Calle 71, San Francisco, Panama City, Panama
The price is P5,727 per night from Aug 1 to Aug 2
P5,727
P6,300 total
Aug 1 - Aug 2
includes taxes & fees
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,018 reviews)
"Nice breakfast as well!"

Reviewed on Jul 2, 2025

Ramada Plaza By Wyndham Panama Punta Pacífica
Megapolis Hotel Panamá
Megapolis Hotel Panamá
4.5 out of 5
Avenida Balboa, Panama City
The price is P7,168 per night from Jul 18 to Jul 19
P7,168
P7,885 total
Jul 18 - Jul 19
includes taxes & fees
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
8.2/10 Very Good! (934 reviews)
"The hotel is beautiful and our suite was very spacious. Felt like home away from home."

Reviewed on Jul 3, 2025

Megapolis Hotel Panamá
Decapolis Hotel Panama City
Decapolis Hotel Panama City
4 out of 5
Avenida Balboa Con Multicentro, Panama City, Panama
The price is P5,243 per night from Jul 7 to Jul 8
P5,243
P5,767 total
Jul 7 - Jul 8
includes taxes & fees
Stay at this 4-star spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (1,222 reviews)
"The property is centrally located within walking distance to a diverse selection of local restaurants, pharmacy, grocery stores, and shopping areas, which is a plus. Their continental breakfast was amazing, and the rooms were clean and comfortable. The staff, specially the young ladies lack customer ..."

Reviewed on Jun 30, 2025

Decapolis Hotel Panama City
Las Americas Golden Tower Panama
Las Americas Golden Tower Panama
4 out of 5
Av. Balboa con Calle 53, Paitilla, Panama City, Panama
The price is P8,629 per night from Aug 2 to Aug 3
P8,629
P9,492 total
Aug 2 - Aug 3
includes taxes & fees
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,000 reviews)
"Good hotel for the price that I paid"

Reviewed on Jun 30, 2025

Las Americas Golden Tower Panama
See all 1,345 properties in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around San Francisco

Summer time in Panama City, blue sky and sunny days to enjoy this city. #lifeatexpedia #PanamaCity #travel

Obarrio

Unique features of Obarrio include the casinos and coffeehouses. Make a stop by Calle 50 or Soho City Center while you're exploring the area.

Obarrio
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Punta Pacifica

Notable for its seaside views, restaurants, and casinos, Punta Pacifica is a sought-after destination for many travelers visiting Panama City. If you want to see some sights in the area, check out Avenida Balboa or Multiplaza Pacific Mall.

Punta Pacifica
Hard Rock Hotel Panama #StunningStructures

Punta Paitilla

Travelers come to Punta Paitilla for its abundant dining options, and you can see top attractions like Avenida Balboa and Multicentro Panama while you're in town.

Punta Paitilla
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Campo Alegre

If you're spending some time in Campo Alegre, Uruguay Street and Calle 50 are top sights worth seeing.

Campo Alegre
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Pueblo Nuevo

While Pueblo Nuevo might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like El Dorado Mall and Multiplaza Pacific Mall.

Pueblo Nuevo
Panama viejo

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

El Cangrejo

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