Name: 21C Museum Hotel St Louis
Price range: P10,413
Rating: 9

Where to stay in Northeast Missouri

Clayton

If you're looking for abundant dining options, a trip to Clayton might be just the ticket. Explore top sights in the area like Chapel of St. Timothy And St. Titus, Concordia Seminary and get around town on the metro at Clayton Station.

Central West End

The ample dining options and lush forests are just a few popular features of the neighborhood. Make a stop by Cathedral Basilica of St. Louis or World Chess Hall of Fame while you're visiting, and jump aboard the metro at Central West End Station to get around town.

Downtown West

If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Saint Louis Abbey while you're in town.

Soulard

You'll enjoy the bars and churches in Soulard. You might want to make time for a stop at Anheuser-Busch Brewery or Soulard Farmer's Market.

"The first St. Charles Borromeo Church, like this one, was constructed of vertical, hewn logs placed directly in the ground: an architectural style unique to the French in the New World during the 17th and 18th centuries. The church has been rebuilt on its original location. Jesse Francis, a local preservationist with 20 years experience restoring 18th French log buildings, directed the reconstruction. The work was done completely by with period tools in the manner of the 18th century. The church is part of an on-going historical interpretive program based on a re-creation of daily activities in this old French village."

St. Charles Historic District

St. Charles Historic District is known for its abundant dining options, and you can plan a trip to Historic Main Street and Missouri River while you're in town.

Top hotels in Northeast Missouri

Hollywood Casino & Hotel St. Louis

777 Casino Center Drive, Maryland Heights, MO

P4,496

P5,896 total

includes taxes & fees

Feb 4 - Feb 5

Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...

8.2/10 Very Good! (1,766 reviews)

"Absolutely love this place! Room was extremely clean and well stocked with all the necessities. Room was very nice and comfortable. So many awesome dining options right on the property, and the casino is awesome! 10/10 highly recommended. I will be staying here again asap!"

Reviewed on Jan 8, 2025

Clayton Plaza Hotel & Extended Stay

7750 Carondelet Avenue, St. Louis, MO

P5,548

P6,463 total

includes taxes & fees

Feb 2 - Feb 3

Stay at this 3.5-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...

8.8/10 Excellent! (2,932 reviews)

"We had a wonderful stay and will definitely be back."

Reviewed on Jan 5, 2025

21C Museum Hotel St Louis

1528 Locust street, St. Louis, MO

P10,413

P12,467 total

includes taxes & fees

Feb 9 - Feb 10

Stay at this 4.5-star luxury hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the restaurant in our ...

9/10 Wonderful! (890 reviews)

"Air filter in room looks like it hadn’t been changed since they built a place. Lights in room aren’t all working."

Reviewed on Jan 5, 2025

See all 2,801 properties in Northeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

St. Louis Union Station

You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's fascinating museums or attend a baseball game.

Busch Stadium

Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's great live music or attend a baseball game.

St. Louis Zoo

In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.

Forest Park

Nature, history and cultural institutions come together in one of the United States’ largest urban parks, which buzzes with St. Louis’ dynamic community spirit.

City Museum

A rooftop Ferris wheel, an indoor tree house and a life-size, walk-through model of a whale; just some of the exhibits in this one-of-a-kind children's museum.