Are there any 5-star vacation rentals in Florida Keys?

Our site doesn't offer any 5-star vacation rentals in Florida Keys. However, you will still find a few top-rated properties where the only item on your itinerary will be to unpack and have fun. See what's available by searching through our vacation rentals in Florida Keys .

Higgs Beach showing tropical scenes and a beach as well as a large group of people

Florida Keys 5 Stars Hotels

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Top Florida Keys 5 Stars Hotels

"Had a great stay"

P18,413 total

includes taxes & fees

Jul 6 - Jul 7

"This is a beautiful resort and the staff is very friendly and competent."

P17,162 total

includes taxes & fees

Jul 2 - Jul 3

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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Florida Keys.

Hawks Cay Resort

61 Hawks Cay Blvd, Marathon, FL

P12,582

P18,148 total

Jul 6 - Jul 7

includes taxes & fees

8/10 Very Good! (1,007 reviews)

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Pool Spa Hot tub Breakfast included Waterpark

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Florida Keys

Snorkel crystal-clear waters teeming with colorful fish, then feast on fresh-caught lobster at a laid-back waterfront shack. Drive the scenic Overseas Highway, stopping at Key West's Ernest Hemingway Home and Dry Tortugas National Park for island adventures.

See all hotels in Florida Keys

Find out more about Florida Keys

Stay in Luxury: 5 Star Hotels in Florida Keys

There's nothing wrong with enjoying the finer things in life. Indulge your every desire on your upcoming leisure time. Treat yourself with a stay in a 5-star hotel during your Florida Keys trip. You'll join the multitudes of holidaymakers who have made Florida Keys so fashionable recently. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Don't wait any longer. Reserve one of our 5-star hotels in Florida Keys and indulge in the finer things in life for a while.

5-Star Hotels in Florida Keys

You'll have a wonderful time at one of these 5-star hotels. Exceptional customer care, luxurious bedding, and deeply relaxing spa offerings are waiting for you. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? 24-hour room service, so you can order that berry tart in the wee hours of the morning? A body scrub that will leave you feeling refreshed and alive? Butler services? Whatever it is your heart desires, you're bound to find it here. Don't want to take our word for it? Explore our listings and pick the perfect accommodation for your needs.

But you aren't going to spend your entire holiday in your room, of course. You're in luck. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Florida Keys are waiting for you to relax after an exciting day.

Make Your Escape

The results are in, and Florida Keys 5-star hotels are the place to be when you book your next holiday. If you've been dreaming about a holiday set here, then go ahead and book it. It's time to plan your next great escape -- this is a great time to find 5-star hotel deals in Florida Keys! Choose one of our Florida Keys 5-star hotels today and soothe yourself in luxe surroundings at your convenience.

Expedia India is rated 4 stars by Feefo based on 1038 reviews

Recent Reviews in Florida Keys

5/5 Excellent

"Great midway location to relax and visit the FL Keys. The property is extremely clean, nice well maintained. The resort feels very secluded yet has easy access to Highway 1. Our room was large, comfortable, and clean with a nice furnished balcony facing the ocean. The food was excellent - it is on the pricey side so keep this in mind when you visit. They also have a large marketplace which offers less expensive food options and specialty coffees and beverages. There is a large family pool with menu service as well as three other smaller pools (plus a beach) if you prefer a more quiet location to swim and soak up the sun. We saw people in every age group including couples/familes/extended families. We loved the resort and highly recommend if you’re looking for a more upscale and pampered environment while visiting the Keys. "

A verified traveler stayed at Isla Bella Beach Resort & Spa

Posted 3 days ago

5/5 Excellent

"This is a beautiful resort and the staff is very friendly and competent."

A verified traveler stayed at Cheeca Lodge & Spa

Posted 6 days ago

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Frequently asked questions

How much does it cost to stay in a 5-star hotel in Florida Keys?

You can find several pricing options for a 5-star hotel in Florida Keys on Expedia. The amount you pay will depend on your travel dates, length of your trip and other factors. Compare all of the available accommodations for your chosen dates and make use of our pricing and other filters to score the ideal upscale stay.

Search for the lowest price per night from P10,244

What makes a hotel 5 stars in Florida Keys?

From gourmet restaurants and 24-hour gyms to pools and deluxe bedding, the 5-star experience in Florida Keys is all about comfort and indulgence. But it calls for more than just top-notch perks to earn a 5-star rating. Stays must also provide outstanding guest-focused services like in-room massage treatments, on-site laundry and dry cleaning and 24/7 room service.

Are there any 5-star all-inclusive resorts in Florida Keys?

Find an indulgent escape that includes your lodging, meals, drinks and entertainment in Florida Keys with Expedia's filters. Search for hotels rated 5 stars and click on the "All inclusive" filter. Double-check what's included in the upfront price. This way, you'll be ready to maximize all the premium perks from the moment you arrive.

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Florida Keys 5 Stars Hotels

Check availability on Florida Keys 5 Star Hotels

Top Florida Keys 5 Stars Hotels

Isla Bella Beach Resort & Spa

Cheeca Lodge & Spa

Explore similar 4-star hotels

Hawks Cay Resort

Amara Cay Resort

Islander Resort

Learn more about Florida Keys

Find out more about Florida Keys

Stay in Luxury: 5 Star Hotels in Florida Keys

5-Star Hotels in Florida Keys

Make Your Escape

Expedia India is rated 4 stars by Feefo based on 1038 reviews

Recent Reviews in Florida Keys

Isla Bella Beach Resort & Spa

Cheeca Lodge & Spa

Explore a world of travel with Expedia

Areas of Florida Keys

Near an Attraction

Hotel Theme

More accommodations in Florida Keys

Recommended cities for you

Most Popular Hotels in Florida Keys

More ways to book

Expedia's Latest Trends

Frequently asked questions